منابع مشابه
Plasma amisulpride levels in schizophrenia or schizoaffective disorder.
The atypical antipsychotic drug amisulpride is a benzamide with specific antagonistic properties, which target dopamine D(2) and D(3) receptors, preferentially in the limbic system. Amisulpride is readily absorbed from the gastrointestinal tract, distributed to all body systems with little binding to plasma proteins. Elimination occurs mainly through the kidneys as unchanged drug. In contrast, ...
متن کاملReview: amisulpride is effective and safe for schizophrenia.
Main results 18 studies (2214 patients) met the selection criteria. Study duration ranged from 3 weeks to 1 year (mean 12 wks). Patients were mostly men in their 30s with moderate to severe schizophrenia (mean duration 3–37 y). Comparators were usually haloperidol and placebo; 4 studies compared amisulpride with flupentixol, perazine, and fluphenazine. Amisulpride led to a greater mean reductio...
متن کاملPm391. the Use of Amisulpride in Treatment of Patients with Residual Schizophrenia
s | 43 positive subscores, whereas no between-group differences were found. A reduction in body weight (p=0.01) and lower levels of total cholesterol (p=0.03), triglycerides (p=0.03), and prolactin (p=0.01) were noted in both groups, but no increase in extrapyramidal symptoms or prolongation of QTC. The blood concentrations of aripiprazole in all patients were in a therapeutic range at day 56, ...
متن کاملAmisulpride versus placebo in the medium-term treatment of the negative symptoms of schizophrenia.
BACKGROUND Amisulpride is a substituted benzamide with high selectivity for dopamine D2 and D3 receptors. The purpose of the study was to evaluate the effect of 100 mg amisulpride in patients with predominantly negative symptoms of schizophrenia. METHOD This was a multi-centre, randomised, parallel-group, double-blind study. Patients received either amisulpride (100 mg/day) or placebo over a ...
متن کاملUpdate on the management of symptoms in schizophrenia: focus on amisulpride
Amisulpride is an atypical antipsychotic drug with a unique receptor pharmacology which is dose dependent. It is a standard treatment in dysthymia as well as in psychosis. Amisulpride is efficacious, effective and well tolerated in positive symptoms of schizophrenia: there is extensive evidence that it treats negative symptoms when given in low doses, although relative lack of EPS and an antide...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1998
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.172.5.450a